Superficial Spreading Squamous Cell Carcinoma of the Cervix with Extension into the Endometrium and Fallopian Tube

Abstract

Squamous cell carcinoma (SCC) of cervix that spreads superficially to the inner surface of the uterus replacing the endometrium with carcinoma cells is called superficial spreading SCC, which is a rare phenomenon. A 65-year-old woman presented with foul smelling, white discharge per vagina since 1 month. Biopsy from cervix and endometrium revealed severe squamous dysplasia. The patient underwent hysterectomy with bilateral salpingo-oophorectomy. Microscopically, the cervix showed carcinoma in situ with upward contiguous superficial spread to the endometrium and left fallopian tube. Immunohistochemistry (IHC) with p16 was strongly positive in the dysplastic stratified squamous epithelium in all the sites. Superficial spreading squamous cell carcinoma in situ of cervix with surface extension into endometrium and fallopian tube is rare and fewer than twenty cases are reported. IHC with p16 was used as a surrogate marker to establish the histogenesis. We are reporting this case with review of literature.

Keywords

• superficial spreading carcinoma
• cervix
• endometrium
• fallopian tube
• p16