Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines

Abstract

Use of the vesicular stomatitis virus (VSV)–based Ebola virus vaccine during outbreaks and the potential use of a similar VSV-based Lassa virus vaccine has raised questions about the vaccines’ stability should the cold chain fail. We demonstrated that current cold chain conditions might tolerate significant variances without affecting efficacy.

Keywords

• Viral hemorrhagic fever
• Ebola virus
• Lassa virus
• vaccine stability
• vaccines
• viruses