Nature Communications (Jul 2021)
Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
- Zhongyuan Bao,
- Yinlong Liu,
- Binglin Chen,
- Zong Miao,
- Yiming Tu,
- Chong Li,
- Honglu Chao,
- Yangfan Ye,
- Xiupeng Xu,
- Guangchi Sun,
- Pengzhan Zhao,
- Ning Liu,
- Yan Liu,
- Xiaoming Wang,
- Sin Man Lam,
- Valerian E. Kagan,
- Hülya Bayır,
- Jing Ji
Affiliations
- Zhongyuan Bao
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Yinlong Liu
- Department of Neurosurgery, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital
- Binglin Chen
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Zong Miao
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Yiming Tu
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Chong Li
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Honglu Chao
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Yangfan Ye
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Xiupeng Xu
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Guangchi Sun
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Pengzhan Zhao
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Ning Liu
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- Yan Liu
- Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University
- Xiaoming Wang
- Department of Immunology, Nanjing Medical University
- Sin Man Lam
- LipidALL Technologies Company Limited
- Valerian E. Kagan
- Center for Free Radical and Antioxidant Heath, Department of Environmental and Occupational Health, University of Pittsburgh
- Hülya Bayır
- Center for Free Radical and Antioxidant Heath, Department of Environmental and Occupational Health, University of Pittsburgh
- Jing Ji
- Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University
- DOI
- https://doi.org/10.1038/s41467-021-24469-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Prokineticin-2 (Prok2) is a secreted protein involved in many physiological processes. Here, the authors show that Prok2 prevents neuronal cell ferroptosis after traumatic brain injury and its administration before cortical injury reduces neuronal degeneration, and motor and cognitive impairments.
