Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice

Tae-Yeon Eom; Seung Baek Han; Jieun Kim; Jay A. Blundon; Yong-Dong Wang; Jing Yu; Kara Anderson; Damian B. Kaminski; Sadie Miki Sakurada; Shondra M. Pruett-Miller; Linda Horner; Ben Wagner; Camenzind G. Robinson; Matthew Eicholtz; Derek C. Rose; Stanislav S. Zakharenko

doi:10.1038/s41467-020-14628-y

Nature Communications (Feb 2020)

Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice

Tae-Yeon Eom,
Seung Baek Han,
Jieun Kim,
Jay A. Blundon,
Yong-Dong Wang,
Jing Yu,
Kara Anderson,
Damian B. Kaminski,
Sadie Miki Sakurada,
Shondra M. Pruett-Miller,
Linda Horner,
Ben Wagner,
Camenzind G. Robinson,
Matthew Eicholtz,
Derek C. Rose,
Stanislav S. Zakharenko

Affiliations

Tae-Yeon Eom: Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
Seung Baek Han: Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
Jieun Kim: Center for In Vivo Imaging and Therapeutics, Cellular Imaging Shared Resource, St. Jude Children’s Research Hospital
Jay A. Blundon: Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
Yong-Dong Wang: Department of Computational Biology, St. Jude Children’s Research Hospital
Jing Yu: Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
Kara Anderson: Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
Damian B. Kaminski: Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
Sadie Miki Sakurada: Center for Advanced Genome Engineering, St. Jude Children’s Research Hospital
Shondra M. Pruett-Miller: Center for Advanced Genome Engineering, St. Jude Children’s Research Hospital
Linda Horner: Cellular Imaging Shared Resource, St. Jude Children’s Research Hospital
Ben Wagner: Cellular Imaging Shared Resource, St. Jude Children’s Research Hospital
Camenzind G. Robinson: Cellular Imaging Shared Resource, St. Jude Children’s Research Hospital
Matthew Eicholtz: Electrical and Electronics Systems Research Division, Oak Ridge National Laboratory
Derek C. Rose: Electrical and Electronics Systems Research Division, Oak Ridge National Laboratory
Stanislav S. Zakharenko: Department of Developmental Neurobiology, St. Jude Children’s Research Hospital

DOI: https://doi.org/10.1038/s41467-020-14628-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Schizophrenia is associated with brain ventricular enlargement. Here, the authors show in mice that 22q11 deletion, which is associated with schizophrenia, causes ventricular enlargement and motility abnormalities in cilia lining ventricle walls via a microRNA mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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