The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Anna G. Antonacopoulou; Konstantina Floratou; Vasiliki Bravou; Anastasia Kottorou; Fotinos-Ioannis Dimitrakopoulos; Stella Marousi; Michalis Stavropoulos; Agelos K. Koutras; Chrisoula D. Scopa; Haralabos P. Kalofonos

doi:10.3233/ACP-CLO-2010-0537

Analytical Cellular Pathology (Jan 2010)

The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Anna G. Antonacopoulou,
Konstantina Floratou,
Vasiliki Bravou,
Anastasia Kottorou,
Fotinos-Ioannis Dimitrakopoulos,
Stella Marousi,
Michalis Stavropoulos,
Agelos K. Koutras,
Chrisoula D. Scopa,
Haralabos P. Kalofonos

Affiliations

Anna G. Antonacopoulou: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
Konstantina Floratou: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
Vasiliki Bravou: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
Anastasia Kottorou: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
Fotinos-Ioannis Dimitrakopoulos: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
Stella Marousi: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
Michalis Stavropoulos: Department of Surgery, Medical School, University of Patras, Rion, Greece
Agelos K. Koutras: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece
Chrisoula D. Scopa: Department of Pathology, Medical School, University of Patras, Rion, Greece
Haralabos P. Kalofonos: Molecular Oncology Laboratory, Medical School, University of Patras, Rion, Greece

DOI: https://doi.org/10.3233/ACP-CLO-2010-0537
Journal volume & issue: Vol. 33, no. 5-6
pp. 177 – 189

Abstract

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Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polymorphisms in CRC. In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin protein were assessed in matched normal and neoplastic colorectal tissue. Moreover, the 9386C/T and −31G/C polymorphisms were investigated.

Published in Analytical Cellular Pathology

ISSN: 2210-7177 (Print); 2210-7185 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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