Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium

Tsunaki Higa; Yasutaka Okita; Akinobu Matsumoto; Shogo Nakayama; Takeru Oka; Osamu Sugahara; Daisuke Koga; Shoichiro Takeishi; Hirokazu Nakatsumi; Naoki Hosen; Sylvie Robine; Makoto M. Taketo; Toshiro Sato; Keiichi I. Nakayama

doi:10.1038/s41467-022-29165-z

Nature Communications (Mar 2022)

Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium

Tsunaki Higa,
Yasutaka Okita,
Akinobu Matsumoto,
Shogo Nakayama,
Takeru Oka,
Osamu Sugahara,
Daisuke Koga,
Shoichiro Takeishi,
Hirokazu Nakatsumi,
Naoki Hosen,
Sylvie Robine,
Makoto M. Taketo,
Toshiro Sato,
Keiichi I. Nakayama

Affiliations

Tsunaki Higa: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Yasutaka Okita: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Akinobu Matsumoto: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Shogo Nakayama: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Takeru Oka: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Osamu Sugahara: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Daisuke Koga: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Shoichiro Takeishi: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Hirokazu Nakatsumi: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Naoki Hosen: Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita
Sylvie Robine: UMR 144, Institut Curie, 75248 Paris Cedex 05
Makoto M. Taketo: Kyoto University Hospital-iACT (Colon Cancer Project), Graduate School of Medicine, Kyoto University
Toshiro Sato: Department of Organoid Medicine, Keio University School of Medicine
Keiichi I. Nakayama: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University

DOI: https://doi.org/10.1038/s41467-022-29165-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

Rapid turnover and regeneration of intestinal epithelium requires distinct intestinal stem cell (ISC) populations. Here the authors show p57 marks quiescent ISCs, and that differentiated cells revert to stem cell state after injury, through dynamic reprogramming characterized by fetal- and metaplastic-like changes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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