ROLE OF THE TRANSFORMING GROWTH FACTOR β1 IN THE GENESIS OF ARTERIAL HYPERTENSION AND ITS COMPLICATIONS

Abstract

Transforming growth factor beta 1 (TGFβ1) is an actively studied cytokine with rather contradictory effects. The article systematizes and summarizes the scientific data on TGFβ1 and its role in the development and progression of arterial hypertension, with an emphasis on arterial stiffness.

Keywords

• arterial hypertension
• arteriosclerosis
• atherosclerosis
• transforming growth factor beta 1
• fibrosis
• endothelin-1
• endothelial-mesenchymal transformation