Data highlighting the expression of two miR-132/212 target genes—Sirt1 and Pten—after chronic stress

Sydney Aten; Chloe E. Page; Anisha Kalidindi; Kelin L. Wheaton; Anzela Niraula; Jon P. Godbout; Kari R. Hoyt; Karl Obrietan

Data in Brief (Dec 2018)

Data highlighting the expression of two miR-132/212 target genes—Sirt1 and Pten—after chronic stress

Sydney Aten,
Chloe E. Page,
Anisha Kalidindi,
Kelin L. Wheaton,
Anzela Niraula,
Jon P. Godbout,
Kari R. Hoyt,
Karl Obrietan

Affiliations

Sydney Aten: Department of Neuroscience, Ohio State University, Columbus, OH, USA
Chloe E. Page: Department of Neuroscience, Ohio State University, Columbus, OH, USA
Anisha Kalidindi: Department of Neuroscience, Ohio State University, Columbus, OH, USA
Kelin L. Wheaton: Division of Pharmaceutics and Pharmaceutical Chemistry, Ohio State University, Columbus, OH, USA
Anzela Niraula: Department of Neuroscience, Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA
Jon P. Godbout: Department of Neuroscience, Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA; Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, OH, USA
Kari R. Hoyt: Division of Pharmaceutics and Pharmaceutical Chemistry, Ohio State University, Columbus, OH, USA
Karl Obrietan: Department of Neuroscience, Ohio State University, Columbus, OH, USA; Corresponding author.

Journal volume & issue: Vol. 21
pp. 2323 – 2329

Abstract

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The data presented here are related to our research article entitled “miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior” (Aten et al., 2018). In this article, we utilize immunofluorescent techniques to examine the protein-level expression of two microRNA-132/212 target genes, Sirt1 and Pten, in miR-132 transgenic and miR-132/212 conditional knockout (cKO) mouse lines. Additionally, using immunohistochemistry, we detail the expression profile of Sirt1 and Pten in the hippocampus and amygdala of WT mice after a 15 day chronic restraint stress paradigm.

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

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