Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease

Katharina Hopp; Victoria A. Catenacci; Nidhi Dwivedi; Timothy L. Kline; Wei Wang; Zhiying You; Dustin T. Nguyen; Kristen Bing; Bhavya Poudyal; Ginger C. Johnson; Matthew R. Jackman; Marsha Miller; Cortney N. Steele; Natalie J. Serkova; Paul S. MacLean; Raphael A. Nemenoff; Berenice Gitomer; Michel Chonchol; Kristen L. Nowak

iScience (Jan 2022)

Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease

Katharina Hopp,
Victoria A. Catenacci,
Nidhi Dwivedi,
Timothy L. Kline,
Wei Wang,
Zhiying You,
Dustin T. Nguyen,
Kristen Bing,
Bhavya Poudyal,
Ginger C. Johnson,
Matthew R. Jackman,
Marsha Miller,
Cortney N. Steele,
Natalie J. Serkova,
Paul S. MacLean,
Raphael A. Nemenoff,
Berenice Gitomer,
Michel Chonchol,
Kristen L. Nowak

Affiliations

Katharina Hopp: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Corresponding author
Victoria A. Catenacci: Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Nidhi Dwivedi: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Timothy L. Kline: Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA; Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
Wei Wang: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Zhiying You: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Dustin T. Nguyen: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Kristen Bing: Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Bhavya Poudyal: Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN 55901, USA
Ginger C. Johnson: Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Matthew R. Jackman: Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Marsha Miller: Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Cortney N. Steele: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Natalie J. Serkova: Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Paul S. MacLean: Department of Medicine, Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Raphael A. Nemenoff: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Berenice Gitomer: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Michel Chonchol: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Kristen L. Nowak: Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Corresponding author

Journal volume & issue: Vol. 25, no. 1
p. 103697

Abstract

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Summary: Progression of autosomal dominant polycystic kidney disease (ADPKD) is modified by metabolic defects and obesity. Indeed, reduced food intake slows cyst growth in preclinical rodent studies. Here, we demonstrate the feasibility of daily caloric restriction (DCR) and intermittent fasting (IMF) in a cohort of overweight or obese patients with ADPKD. Clinically significant weight loss occurred with both DCR and IMF; however, weight loss was greater and adherence and tolerability were better with DCR. Further, slowed kidney growth correlated with body weight and visceral adiposity loss independent of dietary regimen. Similarly, we compared the therapeutic efficacy of DCR, IMF, and time restricted feeding (TRF) using an orthologous ADPKD mouse model. Only ADPKD animals on DCR lost significant weight and showed slowed cyst growth compared to ad libitum, IMF, or TRF feeding. Collectively, this supports therapeutic feasibility of caloric restriction in ADPKD, with potential efficacy benefits driven by weight loss.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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