Nature Communications (Apr 2019)
Altered steady state and activity-dependent de novo protein expression in fragile X syndrome
- Heather Bowling,
- Aditi Bhattacharya,
- Guoan Zhang,
- Danyal Alam,
- Joseph Z. Lebowitz,
- Nathaniel Bohm-Levine,
- Derek Lin,
- Priyangvada Singha,
- Maggie Mamcarz,
- Rosemary Puckett,
- Lili Zhou,
- Sameer Aryal,
- Kevin Sharp,
- Kent Kirshenbaum,
- Elizabeth Berry-Kravis,
- Thomas A. Neubert,
- Eric Klann
Affiliations
- Heather Bowling
- Center for Neural Science, New York University
- Aditi Bhattacharya
- Center for Neural Science, New York University
- Guoan Zhang
- Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine
- Danyal Alam
- Center for Neural Science, New York University
- Joseph Z. Lebowitz
- Center for Neural Science, New York University
- Nathaniel Bohm-Levine
- Center for Neural Science, New York University
- Derek Lin
- Center for Neural Science, New York University
- Priyangvada Singha
- Centre for Brain Development and Repair, Institute for Stem Cell Biology and Regenerative Medicine
- Maggie Mamcarz
- Center for Neural Science, New York University
- Rosemary Puckett
- Center for Neural Science, New York University
- Lili Zhou
- Department of Pediatrics, Rush University Medical Center
- Sameer Aryal
- Center for Neural Science, New York University
- Kevin Sharp
- Department of Pediatrics, Rush University Medical Center
- Kent Kirshenbaum
- Department of Chemistry, New York University
- Elizabeth Berry-Kravis
- Department of Pediatrics, Rush University Medical Center
- Thomas A. Neubert
- Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine
- Eric Klann
- Center for Neural Science, New York University
- DOI
- https://doi.org/10.1038/s41467-019-09553-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Elevated protein synthesis, and dysregulated mGluR signalling, are documented in fragile X syndrome (FXS) Here the authors use proteomic analysis in a mouse model of FXS, and following mGluR5 stimulation, to identify potential biomarkers for the disease.
