Frontiers in Oncology (Dec 2022)

Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports

  • Peter Solár,
  • Peter Solár,
  • Zdenek Mackerle,
  • Zdenek Mackerle,
  • Michal Hendrych,
  • Michal Hendrych,
  • Petr Pospisil,
  • Radek Lakomy,
  • Hana Valekova,
  • Hana Valekova,
  • Marketa Hermanova,
  • Marketa Hermanova,
  • Radim Jancalek,
  • Radim Jancalek

DOI
https://doi.org/10.3389/fonc.2022.1073036
Journal volume & issue
Vol. 12

Abstract

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High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.

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