Approach to map nanotopography of cell surface receptors

Christian Franke; Tomáš Chum; Zuzana Kvíčalová; Daniela Glatzová; Gregor Jörg Gentsch; Alvaro Rodriguez; Dominic A. Helmerich; Lucas Herdly; Harsha Mavila; Otakar Frank; Tomáš Brdička; Sebastian van de Linde; Marek Cebecauer

doi:10.1038/s42003-022-03152-y

Communications Biology (Mar 2022)

Approach to map nanotopography of cell surface receptors

Christian Franke,
Tomáš Chum,
Zuzana Kvíčalová,
Daniela Glatzová,
Gregor Jörg Gentsch,
Alvaro Rodriguez,
Dominic A. Helmerich,
Lucas Herdly,
Harsha Mavila,
Otakar Frank,
Tomáš Brdička,
Sebastian van de Linde,
Marek Cebecauer

Affiliations

Christian Franke: Institute of Applied Optics and Biophysics, Friedrich Schiller University Jena
Tomáš Chum: Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences
Zuzana Kvíčalová: Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences
Daniela Glatzová: Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences
Gregor Jörg Gentsch: Institute of Applied Optics and Biophysics, Friedrich Schiller University Jena
Alvaro Rodriguez: Department of Electrochemical Materials, J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences
Dominic A. Helmerich: Department of Biotechnology and Biophysics, Biocenter, University of Würzburg
Lucas Herdly: Department of Physics, SUPA, University of Strathclyde
Harsha Mavila: Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences
Otakar Frank: Department of Electrochemical Materials, J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences
Tomáš Brdička: Laboratory of Leukocyte Signalling, Institute of Molecular Genetics, Czech Academy of Sciences
Sebastian van de Linde: Department of Physics, SUPA, University of Strathclyde
Marek Cebecauer: Department of Biophysical Chemistry, J. Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences

DOI: https://doi.org/10.1038/s42003-022-03152-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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A super-resolution localisation-based method is shown to map receptor topography in immune cells, which allows quantitative study of molecules and their interactions at the complex surface nanomorphology of cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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