Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

Simon Haworth; Ruth Mitchell; Laura Corbin; Kaitlin H. Wade; Tom Dudding; Ashley Budu-Aggrey; David Carslake; Gibran Hemani; Lavinia Paternoster; George Davey Smith; Neil Davies; Daniel J. Lawson; Nicholas J. Timpson

doi:10.1038/s41467-018-08219-1

Nature Communications (Jan 2019)

Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

Simon Haworth,
Ruth Mitchell,
Laura Corbin,
Kaitlin H. Wade,
Tom Dudding,
Ashley Budu-Aggrey,
David Carslake,
Gibran Hemani,
Lavinia Paternoster,
George Davey Smith,
Neil Davies,
Daniel J. Lawson,
Nicholas J. Timpson

Affiliations

Simon Haworth: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Ruth Mitchell: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Laura Corbin: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Kaitlin H. Wade: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Tom Dudding: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Ashley Budu-Aggrey: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
David Carslake: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Gibran Hemani: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Lavinia Paternoster: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
George Davey Smith: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Neil Davies: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Daniel J. Lawson: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol
Nicholas J. Timpson: Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol

DOI: https://doi.org/10.1038/s41467-018-08219-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Population structure can bias the results of genetic and epidemiological analysis. Here, Haworth et al. report that fine-scale structure is detectable in apparently homogeneous samples such as ALSPAC when measured very precisely, and remains detectable in UK Biobank despite conventional approaches to account for it.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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