Nature Communications (Jan 2021)
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale
- Damien J. Downes,
- Robert A. Beagrie,
- Matthew E. Gosden,
- Jelena Telenius,
- Stephanie J. Carpenter,
- Lea Nussbaum,
- Sara De Ornellas,
- Martin Sergeant,
- Chris Q. Eijsbouts,
- Ron Schwessinger,
- Jon Kerry,
- Nigel Roberts,
- Arun Shivalingam,
- Afaf El-Sagheer,
- A. Marieke Oudelaar,
- Tom Brown,
- Veronica J. Buckle,
- James O. J. Davies,
- Jim R. Hughes
Affiliations
- Damien J. Downes
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Robert A. Beagrie
- MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Matthew E. Gosden
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Jelena Telenius
- MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Stephanie J. Carpenter
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Lea Nussbaum
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Sara De Ornellas
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Martin Sergeant
- MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Chris Q. Eijsbouts
- Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
- Ron Schwessinger
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Jon Kerry
- MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Nigel Roberts
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Arun Shivalingam
- Chemistry Research Laboratory, Department of Chemistry, University of Oxford
- Afaf El-Sagheer
- Chemistry Research Laboratory, Department of Chemistry, University of Oxford
- A. Marieke Oudelaar
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Tom Brown
- Chemistry Research Laboratory, Department of Chemistry, University of Oxford
- Veronica J. Buckle
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- James O. J. Davies
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Jim R. Hughes
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-020-20809-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Current 3C methods generate low-resolution interaction profiles across the genome or high-resolution profiles at a limited number of loci. Here the authors present Nuclear-Titrated Capture-C which produces high-resolution genome-wide interaction profiles.
