Revista do Instituto de Medicina Tropical de São Paulo (Sep 2014)

FIRST REPORT ON OTOTOXICITY OF MEGLUMINE ANTIMONIATE

  • Cláudia Maria Valete-Rosalino,
  • Maria Helena Araujo-Melo,
  • Débora Cristina de Oliveira Bezerra,
  • Renata Oliveira de Barcelos,
  • Vanessa de Melo-Ferreira,
  • Tânia Salgado de Sousa Torraca,
  • Ana Cristina da Costa Martins,
  • João Soares Moreira,
  • Mirian Catherine Melgares Vargas,
  • Frederico Pereira Bom Braga,
  • Mariza de Matos Salgueiro,
  • Maurício Naoto Saheki,
  • Armando Oliveira Schubach

DOI
https://doi.org/10.1590/S0036-46652014000500012
Journal volume & issue
Vol. 56, no. 5
pp. 439 – 442

Abstract

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Introduction: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. Case Report: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted. Conclusion: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.

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