Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea

Keiji Tabuchi; Hidekazu Murashita; Tadamichi Tobita; Keiko Oikawa; Shigeki Tsuji; Isao Uemaetomari; Akira Hara

Journal of Pharmacological Sciences (Jan 2005)

Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea

Keiji Tabuchi,
Hidekazu Murashita,
Tadamichi Tobita,
Keiko Oikawa,
Shigeki Tsuji,
Isao Uemaetomari,
Akira Hara

Affiliations

Keiji Tabuchi: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan; Corresponding author. FAX: +81-298-53-3147 E-mail: [email protected]
Hidekazu Murashita: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
Tadamichi Tobita: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
Keiko Oikawa: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
Shigeki Tsuji: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
Isao Uemaetomari: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
Akira Hara: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan

Journal volume & issue: Vol. 99, no. 2
pp. 191 – 194

Abstract

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The present study was performed to determine effects of dehydroepiandrosterone sulfate (DHEAS), a neurosteroid, on acoustic injury. Albino guinea pigs were exposed to a 2 kHz pure tone of 120 or 125 dB sound pressure level for 10 min immediately after intravenous administration of DHEAS. Statistically significant improvement in the compound action potential threshold shifts and in amplitude reduction of distortion-product otoacoustic emissions was observed 1 week after the acoustic overexposure in the animals treated with DHEAS. The present results suggest that DHEAS has a protective effect against acoustic injury of the cochlea. Keywords:: dehydroepiandrosterone sulfate (DHEAS), acoustic injury, cochlea

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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