Nature Communications (Aug 2021)
MAIT cells regulate NK cell-mediated tumor immunity
- Emma V. Petley,
- Hui-Fern Koay,
- Melissa A. Henderson,
- Kevin Sek,
- Kirsten L. Todd,
- Simon P. Keam,
- Junyun Lai,
- Imran G. House,
- Jasmine Li,
- Magnus Zethoven,
- Amanda X. Y. Chen,
- Amanda J. Oliver,
- Jessica Michie,
- Andrew J. Freeman,
- Lauren Giuffrida,
- Jack D. Chan,
- Angela Pizzolla,
- Jeffrey Y. W. Mak,
- Timothy R. McCulloch,
- Fernando Souza-Fonseca-Guimaraes,
- Conor J. Kearney,
- Rosemary Millen,
- Robert G. Ramsay,
- Nicholas D. Huntington,
- James McCluskey,
- Jane Oliaro,
- David P. Fairlie,
- Paul J. Neeson,
- Dale I. Godfrey,
- Paul A. Beavis,
- Phillip K. Darcy
Affiliations
- Emma V. Petley
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Hui-Fern Koay
- Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Melissa A. Henderson
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Kevin Sek
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Kirsten L. Todd
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Simon P. Keam
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Junyun Lai
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Imran G. House
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Jasmine Li
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Magnus Zethoven
- Sir Peter MacCallum Department of Oncology, The University of Melbourne
- Amanda X. Y. Chen
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Amanda J. Oliver
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Jessica Michie
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Andrew J. Freeman
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Lauren Giuffrida
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Jack D. Chan
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Angela Pizzolla
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Jeffrey Y. W. Mak
- Institute for Molecular Bioscience, The University of Queensland
- Timothy R. McCulloch
- University of Queensland Diamantina Institute, The University of Queensland
- Fernando Souza-Fonseca-Guimaraes
- University of Queensland Diamantina Institute, The University of Queensland
- Conor J. Kearney
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Rosemary Millen
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Robert G. Ramsay
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Nicholas D. Huntington
- Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne
- James McCluskey
- Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Jane Oliaro
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- David P. Fairlie
- Institute for Molecular Bioscience, The University of Queensland
- Paul J. Neeson
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Dale I. Godfrey
- Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne
- Paul A. Beavis
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- Phillip K. Darcy
- Cancer Immunology Program, Peter MacCallum Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-021-25009-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enhance NK-dependent anti-cancer immunity in mice, thereby hinting a new avenue for cancer therapy.
