Nature Communications (Mar 2019)
Deciphering the complex role of thrombospondin-1 in glioblastoma development
- Thomas Daubon,
- Céline Léon,
- Kim Clarke,
- Laetitia Andrique,
- Laura Salabert,
- Elodie Darbo,
- Raphael Pineau,
- Sylvaine Guérit,
- Marlène Maitre,
- Stéphane Dedieu,
- Albin Jeanne,
- Sabine Bailly,
- Jean-Jacques Feige,
- Hrvoje Miletic,
- Marco Rossi,
- Lorenzo Bello,
- Francesco Falciani,
- Rolf Bjerkvig,
- Andréas Bikfalvi
Affiliations
- Thomas Daubon
- INSERM U1029, Institut Nationale de la Santé et de la Recherche Médicale
- Céline Léon
- INSERM U1029, Institut Nationale de la Santé et de la Recherche Médicale
- Kim Clarke
- Computational Biology Facility, University of Liverpool
- Laetitia Andrique
- INSERM U1029, Institut Nationale de la Santé et de la Recherche Médicale
- Laura Salabert
- INSERM U1029, Institut Nationale de la Santé et de la Recherche Médicale
- Elodie Darbo
- UMR1218 ACTION, Bioinformatic Center CBiB, University of Bordeaux
- Raphael Pineau
- Animal Facility, University Bordeaux
- Sylvaine Guérit
- INSERM U1029, Institut Nationale de la Santé et de la Recherche Médicale
- Marlène Maitre
- INSERM U1215, Neurocenter Magendie, Pathophysiology of Addiction Group
- Stéphane Dedieu
- CNRS UMR 7369, MEDyC
- Albin Jeanne
- CNRS UMR 7369, MEDyC
- Sabine Bailly
- INSERM U1036
- Jean-Jacques Feige
- INSERM U1036
- Hrvoje Miletic
- KG Jebsen Brain Tumor Research Center, University of Bergen
- Marco Rossi
- Neurosurgical Oncology Unit, Department of Oncology and Hemato-Oncology, Humanitas Research Hospital, Universita Degli Studi di Milano
- Lorenzo Bello
- Neurosurgical Oncology Unit, Department of Oncology and Hemato-Oncology, Humanitas Research Hospital, Universita Degli Studi di Milano
- Francesco Falciani
- Computational Biology Facility, University of Liverpool
- Rolf Bjerkvig
- KG Jebsen Brain Tumor Research Center, University of Bergen
- Andréas Bikfalvi
- INSERM U1029, Institut Nationale de la Santé et de la Recherche Médicale
- DOI
- https://doi.org/10.1038/s41467-019-08480-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to the invasive behaviour of GBM cells and promotes resistance to antiangiogenic therapy partially through interaction with CD47.
