Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth

Cezanne Miete; Gonzalo P. Solis; Alexey Koval; Martina Brückner; Vladimir L. Katanaev; Jürgen Behrens; Dominic B. Bernkopf

doi:10.1038/s41467-022-28286-9

Nature Communications (Feb 2022)

Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth

Cezanne Miete,
Gonzalo P. Solis,
Alexey Koval,
Martina Brückner,
Vladimir L. Katanaev,
Jürgen Behrens,
Dominic B. Bernkopf

Affiliations

Cezanne Miete: Experimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-Nürnberg
Gonzalo P. Solis: Department of Cell Physiology and Metabolism, Centre Médical Universitaire, University of Geneva
Alexey Koval: Department of Cell Physiology and Metabolism, Centre Médical Universitaire, University of Geneva
Martina Brückner: Experimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-Nürnberg
Vladimir L. Katanaev: Department of Cell Physiology and Metabolism, Centre Médical Universitaire, University of Geneva
Jürgen Behrens: Experimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-Nürnberg
Dominic B. Bernkopf: Experimental Medicine II, Nikolaus-Fiebiger-Center, Friedrich-Alexander University Erlangen-Nürnberg

DOI: https://doi.org/10.1038/s41467-022-28286-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Wnt/β-catenin signalling is frequently hyperactivated in colorectal carcinoma (CRC). Here the authors show that Gαi2 inhibits this signalling pathway by promoting the condensation of conductin/axin2 and β-catenin degradation, and consequently suppresses CRC growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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