α-cell glucokinase suppresses glucose-regulated glucagon secretion

Davide Basco; Quan Zhang; Albert Salehi; Andrei Tarasov; Wanda Dolci; Pedro Herrera; Ioannis Spiliotis; Xavier Berney; David Tarussio; Patrik Rorsman; Bernard Thorens

doi:10.1038/s41467-018-03034-0

Nature Communications (Feb 2018)

α-cell glucokinase suppresses glucose-regulated glucagon secretion

Davide Basco,
Quan Zhang,
Albert Salehi,
Andrei Tarasov,
Wanda Dolci,
Pedro Herrera,
Ioannis Spiliotis,
Xavier Berney,
David Tarussio,
Patrik Rorsman,
Bernard Thorens

Affiliations

Davide Basco: Center for Integrative Genomics, University of Lausanne
Quan Zhang: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital
Albert Salehi: Department of Clinical Science, UMAS, Division of Islet Cell Physiology
Andrei Tarasov: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital
Wanda Dolci: Center for Integrative Genomics, University of Lausanne
Pedro Herrera: Department of Genetic Medicine and Development
Ioannis Spiliotis: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital
Xavier Berney: Center for Integrative Genomics, University of Lausanne
David Tarussio: Center for Integrative Genomics, University of Lausanne
Patrik Rorsman: Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital
Bernard Thorens: Center for Integrative Genomics, University of Lausanne

DOI: https://doi.org/10.1038/s41467-018-03034-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Glucagon secretion is promoted during hypoglycemia and inhibited by increased glucose levels. Here, Basco et al. show that glucokinase suppresses glucose-regulated glucagon secretion by modulating the intracellular ATP/ADP ratio and the closure of KATP channels in α-cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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