Nature Communications (Jun 2019)
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
- Yueming Zhu,
- Xianghui Zou,
- Angela E. Dean,
- Joseph O’ Brien,
- Yucheng Gao,
- Elizabeth L. Tran,
- Seong-Hoon Park,
- Guoxiang Liu,
- Matthew B. Kieffer,
- Haiyan Jiang,
- Melissa E. Stauffer,
- Robert Hart,
- Songhua Quan,
- Karla J. F. Satchell,
- Nobuo Horikoshi,
- Marcelo Bonini,
- David Gius
Affiliations
- Yueming Zhu
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Xianghui Zou
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Angela E. Dean
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Joseph O’ Brien
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Yucheng Gao
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Elizabeth L. Tran
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Seong-Hoon Park
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Guoxiang Liu
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Matthew B. Kieffer
- Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University
- Haiyan Jiang
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Melissa E. Stauffer
- Scientific Editing Solutions
- Robert Hart
- Department of Medicine, University of Illinois at Chicago
- Songhua Quan
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Karla J. F. Satchell
- Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University
- Nobuo Horikoshi
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- Marcelo Bonini
- Department of Medicine, University of Illinois at Chicago
- David Gius
- Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University
- DOI
- https://doi.org/10.1038/s41467-019-10352-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
The molecular mechanism by which acetylation regulates manganese superoxide dismutase (MnSOD) activity and its oncogenicity is unclear. Here the authors show that an acetylation mimicking MnSOD mutant is a monomer, has peroxidase function and acts as a tumor promoting factor.
