Communications Biology (Mar 2021)

Facile accelerated specific therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria

  • Kristen A. Eller,
  • Thomas R. Aunins,
  • Colleen M. Courtney,
  • Jocelyn K. Campos,
  • Peter B. Otoupal,
  • Keesha E. Erickson,
  • Nancy E. Madinger,
  • Anushree Chatterjee

DOI
https://doi.org/10.1038/s42003-021-01856-1
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Eller et al. develop a Facile Accelerated Specific Therapeutic (FAST) platform of antisense therapeutics that targets MDR bacterial pathogens with peptide nucleic acids (PNAs). This platform designs species and/or sequence specific PNAS based on a bioinformatics toolbox and offers a new delivery approach by repurposing the bacterial Type III secretion system in conjunction with a kill switch to overcome limited transport of PNAs into mammalian cells.