Age and anti-Műllerian hormone: prediction of cumulative pregnancy outcome in in vitro fertilization with diminished ovarian reserve

Abstract

Background: To determine the effects of AMH and age on IVF outcomes in women with DOR and whether the cumulative pregnancy potential after consecutive IVF cycles is age or AMH level depended. Methods: Between January 2014 and December 2018, 466 infertility patients (1004 IVF/ICSI cycles) with AMH ≤1.1 ng/mL were recruited and firstly divided into two groups (Group 1: AMH 0.05). The cumulative OPR per patient increased to 60% in Group A2 and 51.7% in Group A1 after the third transfer but reached a plateau (24.8% in Group B2 and 11.8% in Group B1) after the second ET. Conclusions: For advanced-age women with DOR, AMH level showed as a strong predictor of both ovarian response and pregnancy rate. However, even with extremely lower AMH value, younger women still had higher potential to get pregnancy chance through more attempts at subsequent IVF treatments.

Keywords

• age
• anti-műllerian hormone
• diminished ovarian reserve
• ivf
• ongoing pregnancy rate