Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

• Felipe T. Lee-Montiel,
• Alexander Laemmle,
• Alexander Laemmle,
• Verena Charwat,
• Laure Dumont,
• Caleb S. Lee,
• Nathaniel Huebsch,
• Hideaki Okochi,
• Matthew J. Hancock,
• Brian Siemons,
• Steven C. Boggess,
• Ishan Goswami,
• Evan W. Miller,
• Holger Willenbring,
• Kevin E. Healy

Affiliations

Felipe T. Lee-Montiel

Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States

Alexander Laemmle

Department of Surgery, Division of Transplant Surgery, Liver Center and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, United States

Alexander Laemmle

Institute of Clinical Chemistry and Department of Pediatrics, Inselspital, University Hospital Bern, Bern, Switzerland

Verena Charwat

Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States

Laure Dumont

Department of Surgery, Division of Transplant Surgery, Liver Center and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, United States

Caleb S. Lee

Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States

Nathaniel Huebsch

Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States

Hideaki Okochi

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, CA, United States

Matthew J. Hancock

Veryst Engineering, LLC, Needham, MA, United States

Brian Siemons

Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States

Steven C. Boggess

Department of Chemistry, University of California Berkeley, Berkeley, CA, United States

Ishan Goswami

Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States

Evan W. Miller

Departments of Chemistry and Molecular & Cell Biology, and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, United States

Holger Willenbring

Department of Surgery, Division of Transplant Surgery, Liver Center and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, United States

Kevin E. Healy

Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States