Evaluation of plasma atherogenic index on short-term prognosis of intravascular interventional therapy in patients with acute ischemic stroke

Abstract

Objective To explore the role of plasma atherosclerotic index (AIP) in evaluating the short-term prognosis of endovascular intervention in acute ischemic stroke (AIS) patients of different age groups. Methods From January 2020 to December 2022, AIS patients undergoing intravascular interventional therapy in Linyi People's Hospital were selected and divided into low AIP with young and middle-aged group (group A, 50 cases), high AIP with young and middle-aged group (group B, 81 cases), low AIP with elderly group (group C, 131 cases), and high AIP with elderly group (group D, 100 cases) based on age and AIP. Statistical analysis was conducted using AIP as a short-term prognostic factor. Results There were significant differences in age, blood glucose, history of hypertension, systolic blood pressure, admission NHISS score, TC, TG, HDL-C, LDL-C, albumin and AIP among the four groups (P＜0.05). The good prognosis rates of group A, B, C, and D were 62.0%, 40.7%, 42.7%, and 38.0%, respectively, with statistically significant difference among the four groups (χ2=8.465, P=0.037). Pairwise comparison showed that the good prognosis rates of group B, C, and D were lower than those of group A (P＜0.05). Lower AIP and admission NHISS score were protective factors for a good prognosis in AIS patients (P＜0.05). The optimal critical value for predicting short-term adverse prognosis of patients with AIP was 0.01, with a sensitivity of 66.20%, a specificity of 51.30%, and a area under the curve of 0.611. Conclusion AIP is an independent influencing factor for the short-term prognosis of patients with AIS after endovascular intervention, and it can effectively predict the prognosis, which has a certain clinical application value.

Keywords

• plasma atherogenic index， acute ischemic stroke， intravascular interventional therapy， prognosis