The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

• Anna Wojtuszkiewicz,
• Yehuda G. Assaraf,
• Mirthe Hoekstra,
• Rocco Sciarrillo,
• Gerrit Jansen,
• Godefridus J. Peters,
• Rob Pieters,
• Edwin Sonneveld,
• Gabriele Escherich,
• Gertjan J.L. Kaspers,
• Jacqueline Cloos

Affiliations

Anna Wojtuszkiewicz

Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands

Yehuda G. Assaraf

Dept. of Biology, Technion-Israel Institute of Technology, Haifa, Israel

Mirthe Hoekstra

Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands

Rocco Sciarrillo

Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

Gerrit Jansen

Dept. of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands

Godefridus J. Peters

Dept. of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

Rob Pieters

Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

Edwin Sonneveld

Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands

Gabriele Escherich

Clinic of Pediatric Hematology/Oncology, University Medical Center Eppendorf, Hamburg, Germany

Gertjan J.L. Kaspers

Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands

Jacqueline Cloos

Dept of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands;Dept. of Hematology, VU University Medical Center, Amsterdam, The Netherlands