Nature Communications (Jun 2019)

Substrate-induced conformational dynamics of the dopamine transporter

  • Anne Kathrine Nielsen,
  • Ingvar R. Möller,
  • Yong Wang,
  • Søren G. F. Rasmussen,
  • Kresten Lindorff-Larsen,
  • Kasper D. Rand,
  • Claus J. Loland

DOI
https://doi.org/10.1038/s41467-019-10449-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The dopamine transporter is responsible for termination of neurotransmission through Na+-driven reuptake of neurotransmitter from the extracellular space. Here authors use hydrogen-deuterium exchange mass spectrometry to monitor Na+- and dopamine-induced conformational dynamics of the dopamine transporter.