Nature Communications (Oct 2019)
Evaluation of integrin αvβ6 cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis
- Richard H. Kimura,
- Ling Wang,
- Bin Shen,
- Li Huo,
- Willemieke Tummers,
- Fabian V. Filipp,
- Haiwei Henry Guo,
- Thomas Haywood,
- Lotfi Abou-Elkacem,
- Lucia Baratto,
- Frezghi Habte,
- Rammohan Devulapally,
- Timothy H. Witney,
- Yan Cheng,
- Suhas Tikole,
- Subhendu Chakraborti,
- Jay Nix,
- Christopher A. Bonagura,
- Negin Hatami,
- Joshua J. Mooney,
- Tushar Desai,
- Scott Turner,
- Richard S. Gaster,
- Andrea Otte,
- Brendan C. Visser,
- George A. Poultsides,
- Jeffrey Norton,
- Walter Park,
- Mark Stolowitz,
- Kenneth Lau,
- Eric Yang,
- Arutselvan Natarajan,
- Ohad Ilovich,
- Shyam Srinivas,
- Ananth Srinivasan,
- Ramasamy Paulmurugan,
- Juergen Willmann,
- Frederick T. Chin,
- Zhen Cheng,
- Andrei Iagaru,
- Fang Li,
- Sanjiv S. Gambhir
Affiliations
- Richard H. Kimura
- Department of Radiology, Stanford University
- Ling Wang
- Department of Nuclear Medicine, Peking Union Medical College
- Bin Shen
- Department of Radiology, Stanford University
- Li Huo
- Department of Nuclear Medicine, Peking Union Medical College
- Willemieke Tummers
- Department of Radiology, Stanford University
- Fabian V. Filipp
- Cancer Systems Biology, Institute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1
- Haiwei Henry Guo
- Department of Radiology, Stanford University
- Thomas Haywood
- Department of Radiology, Stanford University
- Lotfi Abou-Elkacem
- Department of Radiology, Stanford University
- Lucia Baratto
- Department of Radiology, Stanford University
- Frezghi Habte
- Department of Radiology, Stanford University
- Rammohan Devulapally
- Department of Radiology, Stanford University
- Timothy H. Witney
- Department of Radiology, Stanford University
- Yan Cheng
- Department of Radiology, Stanford University
- Suhas Tikole
- Cancer Systems Biology, Institute of Computational Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1
- Subhendu Chakraborti
- Department of Radiology, Stanford University
- Jay Nix
- Advanced Light Source, Lawrence Berkeley National Laboratory
- Christopher A. Bonagura
- Art Robbins Instruments
- Negin Hatami
- Department of Radiology, Stanford University
- Joshua J. Mooney
- Department of Medicine, Stanford University
- Tushar Desai
- Department of Internal Medicine, Stanford University
- Scott Turner
- Pliant Therapeutics
- Richard S. Gaster
- Department of Radiology, Stanford University
- Andrea Otte
- Department of Radiology, Stanford University
- Brendan C. Visser
- Department of Surgery, Stanford University
- George A. Poultsides
- Department of Surgery, Stanford University
- Jeffrey Norton
- Department of Surgery, Stanford University
- Walter Park
- Department of Medicine, Stanford University
- Mark Stolowitz
- Department of Radiology, Stanford University
- Kenneth Lau
- Department of Radiology, Stanford University
- Eric Yang
- Department of Pathology, Stanford University
- Arutselvan Natarajan
- Department of Radiology, Stanford University
- Ohad Ilovich
- Department of Radiology, Stanford University
- Shyam Srinivas
- Department of Radiology, Stanford University
- Ananth Srinivasan
- Department of Radiology, Stanford University
- Ramasamy Paulmurugan
- Department of Radiology, Stanford University
- Juergen Willmann
- Department of Radiology, Stanford University
- Frederick T. Chin
- Department of Radiology, Stanford University
- Zhen Cheng
- Department of Radiology, Stanford University
- Andrei Iagaru
- Department of Radiology, Stanford University
- Fang Li
- Department of Nuclear Medicine, Peking Union Medical College
- Sanjiv S. Gambhir
- Department of Radiology, Stanford University
- DOI
- https://doi.org/10.1038/s41467-019-11863-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.
