Materials Today Bio (Feb 2024)
Enhanced EPR effects by tumour stromal cell mimicking nanoplatform on invasive pituitary adenoma
- Junning Ma,
- Wei Yin,
- Xiaojian Zhang,
- Lu Lin,
- Youmei Bao,
- Lisi Dai,
- Hui Cao,
- Honghwei Chen,
- Jianbo Yu,
- Jiqi Yang,
- Yue Zhang,
- Huimin Lan,
- XueYang Li,
- Qiong Huang,
- Dan Yang,
- Yajun Yu,
- Jingyao Chen,
- Chengchen Zhang,
- Li Liu,
- Chen Lei,
- Renya Zhan,
- Fei Liu
Affiliations
- Junning Ma
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China; Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China; Department of Neurosurgery of First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China; Department of Pathology& Pathophysiology and Department of Surgical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Zhe Jiang, 310003, China; Corresponding author. Department of the First Affiliated Hospital, School of Medicine, Zhe Jiang University, China..
- Wei Yin
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Xiaojian Zhang
- Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China
- Lu Lin
- Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China
- Youmei Bao
- School of Medicine Yale University, New Haven, CT, 06510, USA
- Lisi Dai
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China; Department of Pathology& Pathophysiology and Department of Surgical Oncology of Second Affiliated Hospital, Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Hui Cao
- Department of Neurosurgery of First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China
- Honghwei Chen
- Department of Neurosurgery of First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China
- Jianbo Yu
- Department of Neurosurgery of First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China
- Jiqi Yang
- Department of Neurosurgery of First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China
- Yue Zhang
- Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China
- Huimin Lan
- Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China
- XueYang Li
- Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China
- Qiong Huang
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Dan Yang
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Yajun Yu
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Jingyao Chen
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Chengchen Zhang
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Li Liu
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China
- Chen Lei
- Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China
- Renya Zhan
- Zhejiang University School of Medicine, Zhe Jiang, 310003, China; Department of Neurosurgery of First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhe Jiang, 310003, China; Corresponding author. Department of the First Affiliated Hospital, School of Medicine, Zhe Jiang University, Zhe Jiang, 310003, China.
- Fei Liu
- Department of Neurosurgery of Fifth Affiliated Hospital, SunYat-Sen University, Zhuhai, 519000, ZhuHai, China; Sun Yat-Sen University, Guangzhou, 510275, China; Corresponding author. Department of the Fifth Affiliated Hospital, Sunyet-Sen University, Zhu Hai, 519000, China.
- Journal volume & issue
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Vol. 24
p. 100895
Abstract
Rapid advances in nanomedicine have enabled potential applications in cancer therapy. The enhanced permeability and retention (EPR) effect is the primary rationale for the passive targeting of nanoparticles in oncology. However, growing evidence indicates that the accumulation of nanomaterials via the EPR effect could be more efficient. Inspired by our clinical observation of the Gap Junction connecpion between folliculostellate cells and pituitary adenoma cells, we designed a novel drug delivery system that targets tumours by coating folliculostellate cell (FS) membranes onto PLGA nanoparticles (NPs). The resulting FSNPs, inheriting membrane proteins from the folliculostellate cell membrane, significantly enhanced the EPR effect compared to nanoparticles without cancer cell membranes. We further demonstrated that mitotane encapsulation improved the therapeutic efficacy of mitotane in both heterotopic and orthotopic pituitary adenoma models. Owing to its significant efficacy, our FS cell membrane-coated nanoplatforms has the potential to be translated into clinical applications for the treatment of invasive pituitary adenoma.
