Nature Communications (Jul 2022)
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
- Fanlin Li,
- Huihui Zhang,
- Wanting Wang,
- Puyuan Yang,
- Yue Huang,
- Junshi Zhang,
- Yaping Yan,
- Yuan Wang,
- Xizhong Ding,
- Jie Liang,
- Xinyue Qi,
- Min Li,
- Ping Han,
- Xiaoqing Zhang,
- Xin Wang,
- Jiang Cao,
- Yang-Xin Fu,
- Xuanming Yang
Affiliations
- Fanlin Li
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Huihui Zhang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Wanting Wang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Puyuan Yang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Yue Huang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Junshi Zhang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Yaping Yan
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Yuan Wang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Xizhong Ding
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Jie Liang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Xinyue Qi
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Min Li
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Ping Han
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Xiaoqing Zhang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- Xin Wang
- Shanghai Longyao Biotechnology Limited
- Jiang Cao
- Department of Hematology, Affiliated Hospital of Xuzhou Medical University
- Yang-Xin Fu
- The Department of Pathology, University of Texas Southwestern Medical Center
- Xuanming Yang
- Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
- DOI
- https://doi.org/10.1038/s41467-022-32092-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific to malignant T cells, while healthy T cells using diverse TCR β-chains are spared.
