Rapid Determination of Ceftriaxone in Mixed Saliva of Practically Healthy Subjects and Patients with Infectious and Somatic Pathologies

Abstract

A method for spectroscopic determination of ceftriaxone in saliva of healthy subjects and patients with upper respiratory tract Infections was developed. The concentration range is 1-50 mcg/ml. The method is express and simple, and can be used to determine ceftriaxone in clinical tests and pharmacokinetic studies. Possible determination of ceftriaxone in aqueous solutions was demonstrated which is useful in analysis of drugs.

Keywords

• ceftriaxone
• aqueous media
• mixed saliva
• uv spectroscopy
• pharmacokinetics