Nature Communications (Aug 2021)
Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer
- Tina Cascone,
- Annikka Weissferdt,
- Myrna C. B. Godoy,
- William N. William,
- Cheuk H. Leung,
- Heather Y. Lin,
- Sreyashi Basu,
- Shalini S. Yadav,
- Apar Pataer,
- Kyle G. Mitchell,
- Md Abdul Wadud Khan,
- Yushu Shi,
- Cara Haymaker,
- Luisa M. Solis,
- Edwin R. Parra,
- Humam Kadara,
- Ignacio I. Wistuba,
- Padmanee Sharma,
- James P. Allison,
- Nadim J. Ajami,
- Jennifer A. Wargo,
- Robert R. Jenq,
- Don L. Gibbons,
- J. Jack Lee,
- Stephen G. Swisher,
- Ara A. Vaporciyan,
- John V. Heymach,
- Boris Sepesi
Affiliations
- Tina Cascone
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Annikka Weissferdt
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Myrna C. B. Godoy
- Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center
- William N. William
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Cheuk H. Leung
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Heather Y. Lin
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Sreyashi Basu
- The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center
- Shalini S. Yadav
- The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center
- Apar Pataer
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Kyle G. Mitchell
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Md Abdul Wadud Khan
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Yushu Shi
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Cara Haymaker
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Luisa M. Solis
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Edwin R. Parra
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Humam Kadara
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Padmanee Sharma
- The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center
- James P. Allison
- The Immunotherapy Platform, The University of Texas MD Anderson Cancer Center
- Nadim J. Ajami
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Jennifer A. Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Robert R. Jenq
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- J. Jack Lee
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Stephen G. Swisher
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Ara A. Vaporciyan
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- John V. Heymach
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Boris Sepesi
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-25188-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Granulomatous/sarcoid-like lesions have been reported in patients treated with immune checkpoint inhibitors (ICIs). Here the authors report the occurrence of “nodal immune flare”, an apparent radiological cancer progression in the nodes characterized by the absence of cancer and the presence of non-caseating granulomas, in patients with non-small cell lung cancer following neoadjuvant ICI treatment.
