The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation

Shengyang Jiang; Changfa Guo; Wei Zhang; Wenliang Che; Wenliang Che; Jie Zhang; Shaowei Zhuang; Yiting Wang; Yiting Wang; Yangyang Zhang; Yangyang Zhang; Ban Liu

doi:10.3389/fgene.2019.00526

Frontiers in Genetics (Jun 2019)

The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation

Shengyang Jiang,
Changfa Guo,
Wei Zhang,
Wenliang Che,
Wenliang Che,
Jie Zhang,
Shaowei Zhuang,
Yiting Wang,
Yiting Wang,
Yangyang Zhang,
Yangyang Zhang,
Ban Liu

Affiliations

Shengyang Jiang: Department of Cardiology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China
Changfa Guo: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
Wei Zhang: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Wenliang Che: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Wenliang Che: Department of Cardiology, Shanghai Tenth People’s Hospital Chongming Branch, Tongji University School of Medicine, Shanghai, China
Jie Zhang: Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Shaowei Zhuang: Department of Cardiology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yiting Wang: Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Yiting Wang: Basic Medical College, Jinzhou Medical University, Jinzhou, China
Yangyang Zhang: Key Laboratory of Arrhythmias, Ministry of Education, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Yangyang Zhang: Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Ban Liu: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fgene.2019.00526
Journal volume & issue: Vol. 10

Abstract

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Atrial fibrillation (AF) is the most common irregular heart rhythm which influence approximately 1–2% of the general population. As a potential factor for ischemic stroke, AF could also cause heart failure. The mechanisms behind AF pathogenesis is complex and remains elusive. As a new category of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) have been known as the key of developmental processes, regulation of cell function, pathogenesis of heart diseases and pathological responses which could provide novel sight into the pathogenesis of AF. circRNAs function as modulators of microRNAs in cardiac disease. To investigate the regulatory mechanism of circRNA in AF, especially the complex interactions among circRNA, microRNA and mRNA, we collected the heart tissues from three AF patients and three healthy controls and profiled their circRNA expressions with circRNA Microarray. The differentially expressed circRNAs were identified and the biological functions of their interaction microRNAs and mRNAs were analyzed. Our results provided novel insights of the circRNA roles in AF and proposed highly possible interaction mechanisms among circRNAs, microRNAs, and mRNAs.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

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