Effect of viscous soluble dietary fiber on glucose and lipid metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis on randomized clinical trials

Kun Lu; Tingqing Yu; Xinyi Cao; Hui Xia; Shaokang Wang; Guiju Sun; Liang Chen; Wang Liao

doi:10.3389/fnut.2023.1253312

Frontiers in Nutrition (Aug 2023)

Effect of viscous soluble dietary fiber on glucose and lipid metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis on randomized clinical trials

Kun Lu,
Tingqing Yu,
Xinyi Cao,
Hui Xia,
Shaokang Wang,
Guiju Sun,
Liang Chen,
Wang Liao

Affiliations

Kun Lu: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China
Tingqing Yu: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China
Xinyi Cao: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China
Hui Xia: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China
Shaokang Wang: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China
Guiju Sun: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China
Liang Chen: Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, China
Wang Liao: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China

DOI: https://doi.org/10.3389/fnut.2023.1253312
Journal volume & issue: Vol. 10

Abstract

Read online

BackgroundThe effect of viscous soluble dietary fiber on glucose and lipid metabolism in type 2 diabetes mellitus (T2DM) remains controversial, and the dose–response relationship of its effect on blood glucose and blood lipid level is still unclear.MethodsWe conducted comprehensive searches in several databases up to 17 January 2023. We conducted a dose–response analysis of randomized controlled trials (RCTs) to investigate the effect of viscous dietary fiber on glucose and lipid metabolism in patients with T2DM.ResultsStatistical significance was observed in the decreases of glycosylated hemoglobin (HbA1c) (mean difference) [MD = −0.47; 95%CI: (−0.66, −0.27)], fasting blood glucose (FBG) [MD = −0.93; 95%CI: (−1.46, −0.41)], total cholesterol (TC) [MD = −0.33; 95%CI: (−0.46, −0.21)], and low-density lipoprotein and cholesterol (LDL-C) [MD = −0.24; 95%CI: (−0.35, −0.13)]. Contrarily, no difference was observed regarding the level of high-density lipoprotein cholesterol (HDL-C) or triglyceride (TG). In addition, the effect on fasting insulin remains unclear. Results from the subgroup analyses showed that an intervention duration longer than 6 weeks had a significant effect on the HbA1c level; a treatment dosage higher than 8.3 g/day had a significant effect on the FBG level.ConclusionsSupplementation of viscous dietary fiber is beneficial to control blood glucose and blood lipid in T2DM.

Published in Frontiers in Nutrition

ISSN: 2296-861X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.frontiersin.org/journals/nutrition/

About the journal

Abstract

Keywords