Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

Alvin Wei Tian Ng; Gianmarco Contino; Sarah Killcoyne; Ginny Devonshire; Ray Hsu; Sujath Abbas; Jing Su; Aisling M. Redmond; Jamie M. J. Weaver; Matthew D. Eldridge; Simon Tavaré; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium; Paul A. W. Edwards; Rebecca C. Fitzgerald

doi:10.1038/s42003-022-03238-7

Communications Biology (Apr 2022)

Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

Alvin Wei Tian Ng,
Gianmarco Contino,
Sarah Killcoyne,
Ginny Devonshire,
Ray Hsu,
Sujath Abbas,
Jing Su,
Aisling M. Redmond,
Jamie M. J. Weaver,
Matthew D. Eldridge,
Simon Tavaré,
Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium,
Paul A. W. Edwards,
Rebecca C. Fitzgerald

Affiliations

Alvin Wei Tian Ng: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
Gianmarco Contino: Institute of Cancer and Genomic Sciences, College of Medical & Dental Sciences, University of Birmingham
Sarah Killcoyne: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
Ginny Devonshire: Cancer Research UK Cambridge Institute, University of Cambridge
Ray Hsu: Department of Surgery, University of Cambridge
Sujath Abbas: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
Jing Su: Cancer Research UK Cambridge Institute, University of Cambridge
Aisling M. Redmond: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
Jamie M. J. Weaver: Cancer Research UK Cambridge Institute, University of Cambridge
Matthew D. Eldridge: Cancer Research UK Cambridge Institute, University of Cambridge
Simon Tavaré: Cancer Research UK Cambridge Institute, University of Cambridge
Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium
Paul A. W. Edwards: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
Rebecca C. Fitzgerald: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge

DOI: https://doi.org/10.1038/s42003-022-03238-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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Genomic structural variants (SVs) in cancer are notoriously difficult to identify, despite the impact they have on cancer progression and treatment efficacy. This study applies state-of-the-art computational methods to catalogue SVs in 383 cases of oesophageal cancer, uncovering mutational patterns and new disease drivers.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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