α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?

Lennart Brodin; Dragomir Milovanovic; Silvio O. Rizzoli; Oleg Shupliakov; Oleg Shupliakov

doi:10.3389/fmolb.2022.891508

Frontiers in Molecular Biosciences (May 2022)

α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?

Lennart Brodin,
Dragomir Milovanovic,
Silvio O. Rizzoli,
Oleg Shupliakov,
Oleg Shupliakov

Affiliations

Lennart Brodin: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Dragomir Milovanovic: Laboratory of Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
Silvio O. Rizzoli: Institute of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany
Oleg Shupliakov: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Oleg Shupliakov: Institute of Translational Biomedicine, St. Petersburg University, St. Petersburg, Russia

DOI: https://doi.org/10.3389/fmolb.2022.891508
Journal volume & issue: Vol. 9

Abstract

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The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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