Nature Communications (Apr 2019)

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

  • Rajiv S. Jumani,
  • Muhammad M. Hasan,
  • Erin E. Stebbins,
  • Liam Donnelly,
  • Peter Miller,
  • Connor Klopfer,
  • Kovi Bessoff,
  • Jose E. Teixeira,
  • Melissa S. Love,
  • Case W. McNamara,
  • Christopher D. Huston

DOI
https://doi.org/10.1038/s41467-019-09880-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Here, the authors provide a panel of medium-throughput assays to test potential drug candidates against different life cycle stages of Cryptosporidium with the goal to support a drug development pipeline that contains compounds with diverse molecular mechanisms of action.