Structural basis for APE1 processing DNA damage in the nucleosome

Tyler M. Weaver; Nicole M. Hoitsma; Jonah J. Spencer; Lokesh Gakhar; Nicholas J. Schnicker; Bret D. Freudenthal

doi:10.1038/s41467-022-33057-7

Nature Communications (Sep 2022)

Structural basis for APE1 processing DNA damage in the nucleosome

Tyler M. Weaver,
Nicole M. Hoitsma,
Jonah J. Spencer,
Lokesh Gakhar,
Nicholas J. Schnicker,
Bret D. Freudenthal

Affiliations

Tyler M. Weaver: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center
Nicole M. Hoitsma: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center
Jonah J. Spencer: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center
Lokesh Gakhar: Department of Biochemistry and Molecular Biology, University of Iowa Carver College of Medicine
Nicholas J. Schnicker: Protein and Crystallography Facility, University of Iowa Carver College of Medicine
Bret D. Freudenthal: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center

DOI: https://doi.org/10.1038/s41467-022-33057-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

AP endonuclease 1 (APE1) processes genomic AP sites during base excision repair. Here, the authors determine the structural mechanism used by APE1 to process nucleosomal AP sites, providing new insight into DNA repair in chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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