Light-Elicited and Oxygen-Saved Iridium Nanocapsule for Oxidative Damage Intensified Oncotherapy

Guobo Chen; Xiang Wang; Zongyan He; Xueyu Li; Zhijin Yang; Yule Zhang; Yuhao Li; Lulu Zheng; Yuqing Miao; Dawei Zhang

doi:10.3390/molecules28114397

Molecules (May 2023)

Light-Elicited and Oxygen-Saved Iridium Nanocapsule for Oxidative Damage Intensified Oncotherapy

Guobo Chen,
Xiang Wang,
Zongyan He,
Xueyu Li,
Zhijin Yang,
Yule Zhang,
Yuhao Li,
Lulu Zheng,
Yuqing Miao,
Dawei Zhang

Affiliations

Guobo Chen: School of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China
Xiang Wang: School of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China
Zongyan He: School of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China
Xueyu Li: School of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China
Zhijin Yang: Shanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China
Yule Zhang: Shanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China
Yuhao Li: School of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China
Lulu Zheng: Shanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China
Yuqing Miao: School of Materials and Chemistry, Institute of Bismuth, University of Shanghai for Science and Technology, Shanghai 200093, China
Dawei Zhang: Shanghai Environmental Biosafety Instruments and Equipment Engineering Technology Research Center, Engineering Research Center of Optical Instrument and System, The Ministry of Education & Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China

DOI: https://doi.org/10.3390/molecules28114397
Journal volume & issue: Vol. 28, no. 11
p. 4397

Abstract

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Regulating redox homeostasis in tumor cells and exploiting oxidative stress to damage tumors is an efficacious strategy for cancer therapy. However, the strengths of organic nanomaterials within this strategy are often ignored. In this work, a light-triggered reactive oxygen species (ROS) damaging nanoamplifier (IrP-T) was developed for enhanced photodynamic therapy (PDT). The IrP-T was fabricated with an amphiphilic iridium complex and a MTH1 inhibitor (TH287). Under green light stimulation, IrP-T catalyzed the oxygen in cells to generate ROS for realizing oxidative damage; meanwhile, TH287 increased the accumulation of 8-oxo-dGTP, further strengthening oxidative stress and inducing cell death. IrP-T could maximize the use of a small amount of oxygen, thus further boosting the efficacy of PDT in hypoxic tumors. The construction of nanocapsules provided a valuable therapeutic strategy for oxidative damage and synergizing PDT.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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