An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Hong-Qing Zhang; Ya-Nan Zhang; Zhe-Rui Zhang; Xiao-Ling Chen; Yan-Yan Hu; Yu-Jia Shi; Jing Wang; Cheng-lin Deng; Bo Zhang; Xiao-Dan Li; Han-Qing Ye

doi:10.1038/s41392-022-01246-x

Signal Transduction and Targeted Therapy (Dec 2022)

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Hong-Qing Zhang,
Ya-Nan Zhang,
Zhe-Rui Zhang,
Xiao-Ling Chen,
Yan-Yan Hu,
Yu-Jia Shi,
Jing Wang,
Cheng-lin Deng,
Bo Zhang,
Xiao-Dan Li,
Han-Qing Ye

Affiliations

Hong-Qing Zhang: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Ya-Nan Zhang: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Zhe-Rui Zhang: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Xiao-Ling Chen: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Yan-Yan Hu: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Yu-Jia Shi: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Jing Wang: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Cheng-lin Deng: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Bo Zhang: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Xiao-Dan Li: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences
Han-Qing Ye: Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41392-022-01246-x
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 4

Abstract

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Published in Signal Transduction and Targeted Therapy

ISSN: 2059-3635 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General)
Website: http://www.nature.com/sigtrans/

About the journal