Nature Communications (Feb 2021)
Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival
- N. Baker,
- C. M. C. Catta-Preta,
- R. Neish,
- J. Sadlova,
- B. Powell,
- E. V. C. Alves-Ferreira,
- V. Geoghegan,
- J. B. T. Carnielli,
- K. Newling,
- C. Hughes,
- B. Vojtkova,
- J. Anand,
- A. Mihut,
- P. B. Walrad,
- L. G. Wilson,
- J. W. Pitchford,
- P. Volf,
- J. C. Mottram
Affiliations
- N. Baker
- York Biomedical Research Institute, University of York
- C. M. C. Catta-Preta
- York Biomedical Research Institute, University of York
- R. Neish
- York Biomedical Research Institute, University of York
- J. Sadlova
- Department of Parasitology, Faculty of Science, Charles University
- B. Powell
- Department of Mathematics, University of York
- E. V. C. Alves-Ferreira
- York Biomedical Research Institute, University of York
- V. Geoghegan
- York Biomedical Research Institute, University of York
- J. B. T. Carnielli
- York Biomedical Research Institute, University of York
- K. Newling
- Department of Biology, University of York
- C. Hughes
- York Biomedical Research Institute, University of York
- B. Vojtkova
- Department of Parasitology, Faculty of Science, Charles University
- J. Anand
- York Biomedical Research Institute, University of York
- A. Mihut
- Department of Biology, University of York
- P. B. Walrad
- York Biomedical Research Institute, University of York
- L. G. Wilson
- York Biomedical Research Institute, University of York
- J. W. Pitchford
- Department of Biology, University of York
- P. Volf
- Department of Parasitology, Faculty of Science, Charles University
- J. C. Mottram
- York Biomedical Research Institute, University of York
- DOI
- https://doi.org/10.1038/s41467-021-21360-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Protein kinases are fundamental in cellular signalling required for Leishmania survival throughout the life cycle. Here, Baker and Catta-Preta et al. report on a kinome-wide functional study in Leishmania mexicana to define protein kinases with roles in life cycle transition.
