Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Elaine Xu; Mafalda M. A. Pereira; Ismene Karakasilioti; Sebastian Theurich; Mona Al-Maarri; Gunter Rappl; Ari Waisman; F. Thomas Wunderlich; Jens C. Brüning

doi:10.1038/ncomms14803

Nature Communications (May 2017)

Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Elaine Xu,
Mafalda M. A. Pereira,
Ismene Karakasilioti,
Sebastian Theurich,
Mona Al-Maarri,
Gunter Rappl,
Ari Waisman,
F. Thomas Wunderlich,
Jens C. Brüning

Affiliations

Elaine Xu: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
Mafalda M. A. Pereira: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
Ismene Karakasilioti: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
Sebastian Theurich: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
Mona Al-Maarri: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
Gunter Rappl: Center for Molecular Medicine Cologne (CMMC) and Department of Internal Medicine I, University of Cologne
Ari Waisman: Institute for Molecular Medicine, University of Medical Centre of the Johannes Gutenberg University of Mainz
F. Thomas Wunderlich: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research
Jens C. Brüning: Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research

DOI: https://doi.org/10.1038/ncomms14803
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Interleukin-6 (IL-6) is increased in obesity and activates T cells to promote inflammation. Here, Xuet al. use mice that lack IL-6 receptors on T cells to uncover the temporal and tissue-specific effects of classic and trans IL-6 signalling on inflammation and insulin resistance on a high-fat diet.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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