Nature Communications (Oct 2021)
Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture
Abstract
Interactions between chromatin and nuclear components and whether these interactions affect development is not well understood. Here the authors show inner nuclear protein Matrin-3 (Matr3) loss leads to accelerated erythroid maturation, and that Matr3 is involved in chromosomal structure organization and compartmentalization to negatively regulate cell differentiation.