Nature Communications (Sep 2022)

Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear

  • Stephanie L. Grella,
  • Amanda H. Fortin,
  • Evan Ruesch,
  • John H. Bladon,
  • Leanna F. Reynolds,
  • Abby Gross,
  • Monika Shpokayte,
  • Christine Cincotta,
  • Yosif Zaki,
  • Steve Ramirez

DOI
https://doi.org/10.1038/s41467-022-32246-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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The hippocampus is a brain region critically involved in memory. In this study, the authors demonstrate that reactivating hippocampal neurons associated with positive memories can disrupt a fear response in mice.