Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

Abstract

4-Fluoropyrazole systems may be prepared by a single, sequential telescoped two-step continuous gas/liquid–liquid/liquid flow process from diketone, fluorine gas and hydrazine starting materials.

Keywords

• continuous flow reactions
• fluorine
• fluoropyrazole
• gas-liquid flow reactor
• selective direct fluorination