Severe hyponatremia due to paraneoplastic syndrome of inappropriate antidiuretic hormone secretion in non-small cell lung carcinoma transforming to small cell lung carcinoma during treatment with immune checkpoint inhibitor

Vicky Mai; Sylvain Trahan; Sylvain Pagé; Mathieu Simon; Catherine Labbé

Current Problems in Cancer: Case Reports (Dec 2021)

Severe hyponatremia due to paraneoplastic syndrome of inappropriate antidiuretic hormone secretion in non-small cell lung carcinoma transforming to small cell lung carcinoma during treatment with immune checkpoint inhibitor

Vicky Mai,
Sylvain Trahan,
Sylvain Pagé,
Mathieu Simon,
Catherine Labbé

Affiliations

Vicky Mai: Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Université Laval, Quebec City, G1V 4G5, Canada; Pulmonary Hypertension Research Group (http://phrg.ca), Quebec City, G1V 4G5, Canada
Sylvain Trahan: Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Université Laval, Quebec City, G1V 4G5, Canada; Department of pathology, Université Laval, Quebec City, G1V 0A6, Canada
Sylvain Pagé: Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Université Laval, Quebec City, G1V 4G5, Canada; Department of pathology, Université Laval, Quebec City, G1V 0A6, Canada
Mathieu Simon: Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Université Laval, Quebec City, G1V 4G5, Canada; Department of Medicine, Université Laval, Quebec City, G1V 0A6, Canada
Catherine Labbé: Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Université Laval, Quebec City, G1V 4G5, Canada; Department of Medicine, Université Laval, Quebec City, G1V 0A6, Canada; Corresponding author at: 2725 Chemin Ste-Foy, Québec G1V 4G5, Canada,.

Journal volume & issue: Vol. 4
p. 100125

Abstract

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This is the first case described of transformation from EGFR wild-type non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) during immunotherapy presenting with severe hyponatremia due to paraneoplastic syndrome of inappropriate antidiuretic hormone secretion.

Published in Current Problems in Cancer: Case Reports

ISSN: 2666-6219 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/current-problems-in-cancer-case-reports/

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