A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels

Maria Ángeles Martínez-Martínez; Camino De Juan Romero; Virginia Fernández; Adrián Cárdenas; Magdalena Götz; Víctor Borrell

doi:10.1038/ncomms11812

Nature Communications (Jun 2016)

A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels

Maria Ángeles Martínez-Martínez,
Camino De Juan Romero,
Virginia Fernández,
Adrián Cárdenas,
Magdalena Götz,
Víctor Borrell

Affiliations

Maria Ángeles Martínez-Martínez: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández
Camino De Juan Romero: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández
Virginia Fernández: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández
Adrián Cárdenas: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández
Magdalena Götz: Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research
Víctor Borrell: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández

DOI: https://doi.org/10.1038/ncomms11812
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The outer subventricular zone (OSVZ) contains basal radial glial cells (bRGC) involved in cortical expansion in gyrencephalic mammals. Here the authors identify a developmental time window with marked production of bRGCs required to found the OSVZ that is dependent on coincident downregulation of Cdh1 and Trnp1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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