Pegloticase-Induced Rapid Uric Acid Lowering and Kidney and Cardiac Health Markers in Youth-Onset Type 2 Diabetes: A Pilot Clinical Trial

• Phoom Narongkiatikhun, MD,
• Sungho Park, PhD,
• Amy Rydin, MD,
• Callie Rountree-Jablin,
• Ye Ji Choi, MPH,
• Jo Ann Antenor, PhD, MPH,
• Laura Pyle, PhD,
• Lynette Driscoll, PA-C, MA,
• Daniel van Raalte, MD,
• Maureen Pushea, CCLS,
• Alyssa Caldwell-McGee, MS,
• Vuddhidej Ophascharoensuk, MD,
• Kristen Nadeau, MD,
• Kalie Tommerdahl, MD,
• Richard J. Johnson, MD,
• Lorna Browne, MD,
• Alex J. Barker, MD,
• Petter Bjornstad, MD

Affiliations

Phoom Narongkiatikhun, MD

Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, University of Washington School of Medicine, Seattle, WA; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Address for Correspondence: Phoom Narongkiatikhun, MD, Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, University of Washington School of Medicine, Seattle, WA.

Sungho Park, PhD

Department of Radiology, Section of Pediatric Radiology, Children’s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Amy Rydin, MD

Department of Pediatrics, Section of Pediatric Endocrinology, Ascension Health and Dell Children’s Medical Group, Austin, TX

Callie Rountree-Jablin

Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO

Ye Ji Choi, MPH

Department of Pediatrics, Section of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO

Jo Ann Antenor, PhD, MPH

Horizon Therapeutics PLC, Deerfield, IL

Laura Pyle, PhD

Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO; Department of Pediatrics, Section of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO

Lynette Driscoll, PA-C, MA

Department of Pediatrics, Section of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO

Daniel van Raalte, MD

Diabetes Center, Department of Internal Medicine, Amsterdam University Medical Centers, Location VUMC, Amsterdam, The Netherlands

Maureen Pushea, CCLS

Department of Pediatrics, Section of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO

Alyssa Caldwell-McGee, MS

Department of Pediatrics, Section of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO

Vuddhidej Ophascharoensuk, MD

Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

Kristen Nadeau, MD

Department of Pediatrics, Section of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO

Kalie Tommerdahl, MD

Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, University of Washington School of Medicine, Seattle, WA

Richard J. Johnson, MD

Division of Nephrology, Rocky Mountain VA Medical Center, Aurora, CO; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO

Lorna Browne, MD

Department of Radiology, Section of Pediatric Radiology, Children’s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Alex J. Barker, MD

Department of Radiology, Section of Pediatric Radiology, Children’s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Petter Bjornstad, MD

Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, University of Washington School of Medicine, Seattle, WA; Department of Pediatrics, Division of Endocrinology, University of Washington School of Medicine, Seattle, WA