Nature Communications (May 2020)
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response
- Magdalena M. Szewczyk,
- Yoshinori Ishikawa,
- Shawna Organ,
- Nozomu Sakai,
- Fengling Li,
- Levon Halabelian,
- Suzanne Ackloo,
- Amber L. Couzens,
- Mohammad Eram,
- David Dilworth,
- Hideto Fukushi,
- Rachel Harding,
- Carlo C. dela Seña,
- Tsukasa Sugo,
- Kozo Hayashi,
- David McLeod,
- Carlos Zepeda,
- Ahmed Aman,
- Maria Sánchez-Osuna,
- Eric Bonneil,
- Shinji Takagi,
- Rima Al-Awar,
- Mike Tyers,
- Stephane Richard,
- Masayuki Takizawa,
- Anne-Claude Gingras,
- Cheryl H. Arrowsmith,
- Masoud Vedadi,
- Peter J. Brown,
- Hiroshi Nara,
- Dalia Barsyte-Lovejoy
Affiliations
- Magdalena M. Szewczyk
- Structural Genomics Consortium, University of Toronto
- Yoshinori Ishikawa
- Research, Takeda Pharmaceutical Company Limited
- Shawna Organ
- Structural Genomics Consortium, University of Toronto
- Nozomu Sakai
- Research, Takeda Pharmaceutical Company Limited
- Fengling Li
- Structural Genomics Consortium, University of Toronto
- Levon Halabelian
- Structural Genomics Consortium, University of Toronto
- Suzanne Ackloo
- Structural Genomics Consortium, University of Toronto
- Amber L. Couzens
- Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute
- Mohammad Eram
- Structural Genomics Consortium, University of Toronto
- David Dilworth
- Structural Genomics Consortium, University of Toronto
- Hideto Fukushi
- Research, Takeda Pharmaceutical Company Limited
- Rachel Harding
- Structural Genomics Consortium, University of Toronto
- Carlo C. dela Seña
- Structural Genomics Consortium, University of Toronto
- Tsukasa Sugo
- Research, Takeda Pharmaceutical Company Limited
- Kozo Hayashi
- Research, Takeda Pharmaceutical Company Limited
- David McLeod
- Drug Discovery Program, Ontario Institute for Cancer Research
- Carlos Zepeda
- Drug Discovery Program, Ontario Institute for Cancer Research
- Ahmed Aman
- Drug Discovery Program, Ontario Institute for Cancer Research
- Maria Sánchez-Osuna
- Institute for Research in Immunology and Cancer (IRIC) University of Montreal
- Eric Bonneil
- Institute for Research in Immunology and Cancer (IRIC) University of Montreal
- Shinji Takagi
- Research, Takeda Pharmaceutical Company Limited
- Rima Al-Awar
- Drug Discovery Program, Ontario Institute for Cancer Research
- Mike Tyers
- Institute for Research in Immunology and Cancer (IRIC) University of Montreal
- Stephane Richard
- Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University
- Masayuki Takizawa
- Research, Takeda Pharmaceutical Company Limited
- Anne-Claude Gingras
- Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute
- Cheryl H. Arrowsmith
- Structural Genomics Consortium, University of Toronto
- Masoud Vedadi
- Structural Genomics Consortium, University of Toronto
- Peter J. Brown
- Structural Genomics Consortium, University of Toronto
- Hiroshi Nara
- Research, Takeda Pharmaceutical Company Limited
- Dalia Barsyte-Lovejoy
- Structural Genomics Consortium, University of Toronto
- DOI
- https://doi.org/10.1038/s41467-020-16271-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Protein arginine methyltransferases (PRMTs) are increasingly recognized as potential therapeutic targets but PRMT7 remains an understudied member of this enzyme family. Here, the authors develop a chemical probe for PRMT7 and apply it to elucidate the role of PRMT7 in the cellular stress response.
