Biomedicines (Apr 2024)

Effects of Short-, Medium-, and Long-Term Treatment Using Photobiomodulation Therapy Combined with Static Magnetic Field in Aging Rats

  • Kadma Karênina Damasceno Soares Monteiro,
  • Shaiane Silva Tomazoni,
  • Gianna Móes Albuquerque Pontes,
  • Adeilson Matias Teixeira,
  • Fernanda Aparecida de Araújo Agra,
  • Carolina Barros Alvim,
  • Sâmela Lopes Medeiros Brigato,
  • Rodrigo Labat Marcos,
  • Humberto Dellê,
  • Andrey Jorge Serra,
  • Ernesto Cesar Pinto Leal-Junior

DOI
https://doi.org/10.3390/biomedicines12050990
Journal volume & issue
Vol. 12, no. 5
p. 990

Abstract

Read online

(1) Background: We investigated the detrimental and protective effects of short-, medium, and long-term treatment with different doses of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) during the aging process. (2) Methods: Rats were treated for 15, 30, and 60 weeks with 1, 3, 10, and 30 J of PBMT-sMF or a placebo control. In addition, eight young rats were not subjected to any procedure or treatment and were euthanized at six weeks old. Skin, muscle, bone, kidney, liver, and blood samples were analyzed. (3) Results: No differences between the groups in the morphology of the skin, muscle, and bone was observed. Glutamic pyruvic transaminase levels were increased in the placebo group after 30 and 60 weeks. Glutamic oxaloacetic transaminase levels were also increased in the placebo group after 30 weeks. An increase in creatinine in the PBMT-sMF 3, 10, and 30 J groups compared with that in the young control group was observed. No significant difference in urea levels between the groups was noted. Vascular endothelial growth factor increased in the PBMT-sMF 10 and 30 J groups after 15 weeks of treatment and in the PBMT-sMF 3 J after 60 weeks. Finally, vascular endothelial growth factor decreased in the PBMT-sMF 30 J group after 30 weeks of treatment. (4) Conclusions: PBMT-sMF did not have detrimental effects on the skin, muscle, bone, kidney, or liver after short-, medium-, and long-term treatments in aging rats. In addition, PBMT-sMF may have protective effects on the muscle tissue in aging rats after short- and long-term treatment.

Keywords